中文摘要：

目的 研究慢性碘过量对缺碘wistar大鼠甲状腺形态的影响。方法 4周龄Wistar大鼠经低碘饲料喂养3个月建立缺碘大鼠模型，对其进行8个月的1倍、3倍和6倍补碘，补碘量分别对应于笔者前期流行病调查所见的3个农村社区的碘摄入水平，后两者为碘过量。观察缺碘大鼠经不同卉3量补碘后甲状腺形态学的变化。结果 在补充1倍、3倍和6倍碘8个月后，甲状腺碘含量增加，甚至高于非缺碘大鼠；甲状腺相对重量仍然未能回落至非缺碘大鼠水平。电镜下缺碘引起的内质网扩张和线粒体肿大在补碘后来见恢复。且随补碘剂量的增加，超微结构损伤呈现加重的趋势。结论 对缺碘动物单纯补碘难以纠正基础缺碘引起的甲状腺损伤。甲状腺内碘潴留，甲状腺肿仍然存在，甲状腺可能处于亚临床病理状态。

英文摘要：

[Objective] To study the effect of chronic excessive iodine on thyroid morphology of iodine-deficient rats. [Methods] Iodine-deficient rat models were made by giving 4-week old rats iodine-deficient fodder for 3 months. These iodine-deficient rats were then supplemented for 8 months 1-, 3- and 6- fold iodine which corresponded to the 3 levels of iodine intake found in our epidemiological study in 3 rural communities, the latter two levels were iodine excessive. Then changes in thyroid morphology after iodine supplement were observed. [Results] After supplement of 1-, 3- and 6-fold iodine to iodine-deficient rats for 8 months. Thyroid iodine content increased to the level higher than non-iodine-deficient rats. thyroid relative weight decreased, but was higher than non-iodine-deficient ones. The ultrastructure injures of swelling mitochondria and dilating endoplasmic reticulum in epithelial cells of iodine-deficient thyroid did not recover, but became worse with iodine supplement increase. [Conelusion] Iodine supplement alone could not correct the injures resulting from iodine deficiency with iodine accumulating in thyroid and goiter remaining. A sub-pathological state of thyroid might occur.