中文摘要：

背景：生物涂层假体在体内植入,受到复杂的化力学交互作用,临床返修病例随即增多。目的：总结化力学交互作用对热喷涂生物活性涂层的组织与性能影响方面的研究现状与进展。方法：应用计算机检索Elsevier数据库1999-01/2009-11的相关文章。检索词＂apatite,coating,spraying＂,限定文章语言种类为English。同时计算机检索维普数据库1989-01/2009-11的相关文章,检索词＂磷灰石,涂层,喷涂＂,限定文章语言种类为中文。纳入文章与热喷涂生物活性涂层的化力学作用密切相关的论文。排除重复性研究及与课题相关性较弱的文献。结果与结论：力学环境对生物活性涂层的溶解有显著作用,拉应力促进溶解而压应力抑制溶解。另外涂层溶解过程中涂层的力学性能同时受到影响,经过模拟体液浸泡后,涂层的力学性能下降。而植入体内后,由于骨组织参与及生物环境的影响,涂层性能有所升高。但目前仅有简单载荷对涂层组织与性能影响方面的研究,亟需进行拉、扭、疲劳等复合载荷与人体特殊化学环境的耦合场作用下,生物活性涂层的组织与性能的变化规律研究,以保障其结构完整性与性能完整性。

英文摘要：

BACKGROUND：With the bio-coated prosthesis implanted in the body by a complex interaction of chemo-mechanics,the cases of clinical revision increased.OBJECTIVE：To summarize the research progress of effect of interaction of chemo-mechanics on the microstructure and properties of thermal-sprayed bioactive coatings.METHODS：The relevant articles were retrieved from Elsevier with the key words of＂apatite,coating,spraying＂in English between January 1999 to November 2009.Meanwhile,the relevant articles were searched from database of Vip Information with the key words of＂apatite,coating,spraying＂in Chinese between January 1989 to November 2009.The articles that were highly related to the effect of chemo-mechanics on the microstructure and properties of thermal-sprayed bio-coatings were collected.The repetitive researching results and those with weak correlation were excluded.RESULTS AND CONCLUSION：It was shown that loading affected the dissolution of bio-coatings significantly.Tensile stress promoted the dissolution,while compressive stress inversely.In addition,the mechanical properties decreased after immersion in simulation body fluid.Moreover,the mechanical properties increased when it was implanted in bone tissue.However,there were only investigation of microstructure and properties of bio-coatings under simple loading.The coupling effect of complex loading,such as tension,torsion and fatigue,etc.,and the specific chemical environment on the bio-coatings should be studied in order to ensure the integrity of its structure and properties.