中文摘要：

以便综合指向的药搬运人系统，磁性的 chitosan-5-fluorouracil nano 粒子被把 5 氟尿嘧啶(5-Fu ) 用作模型药准备，是的 Fe3O4 nano 粒子核，是的 chitosan 是的包围材料和 glutaraldehyde 通过超声的技术的生气连接代理人。磁性的 chitosan-5-Fu nano 粒子的形态学与一台传播电子显微镜(TEM ) 被观察。结果证明磁性的 chitosan-5-Fu nano 粒子与 5060 nm 的一个尺寸范围在球形的结构被准备。释放磁性的 chitosan-5-Fu nano 粒子的性质的交付的能力和药被紫外力的光谱分析调查。结果证明装载能力是 13.4% 并且在磷酸盐缓冲区(pH=7.2 ) 的累积版本百分比答案在 30 h 是 68% 。这些数据显示磁性的 chitosan-5-Fu nano 粒子的包的药是慢慢地释放的。磁性的 chitosan-5-Fu nano 粒子的磁性的反应被紫外力的分光计学习检测答案吸收度的变化。没有外部磁场， nano 粒子免职率是慢的。当受到 8 mT 磁场时，粒子沉积率很快被增加。结果证明磁性的 chitosan-5-Fu nano 粒子有磁性的稳定性和强壮的指向特征。

英文摘要：

In order to synthesize the targeting drug carrier system, magnetic chitosan-5-fluorouracil nano-particles were prepared by using 5-fluorouracil （5-Fu） as model drug, Fe3O4 nano-particles as kernel, chitosan as enveloping material and glutaraldehyde as cross linking agent through ultrasonic technique. The morphology of the magnetic chitosan-5-Fu nano-particles was observed with a transmission electron microscope（TEM）. The results showed that magnetic chitosan-5-Fu nano-particles were prepared in spherical structure with a size range of 50 60 nm. The delivering capacity and drug releasing properties of magnetic chitosan-5-Fu nano-particles were investigated by UV-vis spectrum analysis. The results showed that the loading capacity was 13.4% and the cumulative release percentage in the phosphate buffer （pH 7.2） solutions was 68% in 30 h. These data indicate that the wrapped drug of magnetic chitosan-5-Fu nano-particles was slowly-released. The magnetic response of magnetic chitosan-5-Fu nano-particles was studied by UV-vis spectrometer to detect the changes of solution absorbance. Without external magnetic field, the nano-particle deposition rate was slow. When being subjected to 8 mT magnetic field, the particle sedimentation rate was increased rapidly, The results showed that magnetic chitosan-5-Fu nano-particles have a magnetic stability and strong targeting characteristics.