中文摘要：

作为重要的杂环化合物，合成新的2-噁唑啉衍生物以及发展其新的合成方法具有重要意义，为此以α-氰基肉桂酸乙酯衍生物为底物，以N-溴苯甲酰胺为反应试剂，在无水碳酸钠（相对于底物3为110％摩尔分数）促进下，在丙酮溶剂中，室温下，建立了合成相应2-噁唑啉衍生物的新方法，共合成了11个新化合物，其结构由核磁共振波谱仪（1HNMR，13CNMR）和高分辨质谱（HRMS）确认。结果显示，各种α-氰基肉桂酸乙酯衍生物（3a～3k）可被顺利的转化成相应的2-噁唑啉衍生物（5a～5k）。在室温下，丙酮作溶剂，以Na2CO3为促进剂时，相应产物的最高收率可达90％。不仅α-氰基肉桂酸乙酯衍生物（3）可被用作该反应的底物，而且α-乙氧甲酰基肉桂酸乙酯（6）也适用于该反应。实验结果还证明，除了N-溴代苯甲酰胺外，N-溴代对硝基苯甲酰胺（8）及N-溴代乙酰胺（9）也适用该反应，证明该方法具有广泛的适应性。根据实验结果，提出了可能的反应机理，该机理支持了形成2-噁唑啉衍生物的区域选择性。

英文摘要：

2-0xazoline derivative belongs to an important class of heterocyclic compounds, new synthetic method and new 2-oxazoline derivatives are eagerly desired. In order to develop a new protocol for the synthesis of deferent structural 2-oxazoline derivatives, a method from ethyl α-cyanocinnamate derivatives and N-bromobenzamide has been explored. The structures of all eleven synthesized products were confirmed by proton nuclear magnetic resonance spectroscopy （ 1H NMR）, and mass spectrometry （MS）. The results show that a series of ethyl a-cyanocinnamate derivatives （3a -3k） can be smoothly converted into corresponding 2-oxazoline derivatives（5a-5k）. When Na2CO3 was used as the promoter in acetone at room temperature, the corresponding products were obtained in high yield （ up to 90% ）. Not only can ethyl α-cyanocinnamate derivatives be used as substrate, but also ethyl α-carbethoxy-eyanocinnamate （6） can be employed as the substrate, too. Experiment results indicate that N-bromo-p-nitrobenzamide （8） and N-bromoacetamide （9） can tolerate this reaction except N-bromobenzamide （4）. Above results indicate that the easy and efficient protocol has application in a large scope of electron-deficient olefins and N-bromoamide. A possible mechanism was proposed which can explain well the full regiospeeificity of the reaction.