中文摘要：

为解决抗性问题,寻找新的活性化合物,在前期工作基础上,运用生物等排原理,以吡唑肟醚为骨架,引入了第二代新烟碱类重要药效团氯代噻唑和另一重要基团嘧啶环,设计合成了系列新型吡唑肟醚类化合物.以1^H NMR,IR,元素分析及MS进行结构确证,并进行了杀虫、杀螨及杀菌活性测定.部分具有氯代噻唑环的A系列化合物显示了良好的杀蚊虫活性（100%,5 mg·L^-1）、杀豆蚜活性（100%,200 mg/L）和杀螨活性（100%,200 mg/L）;具有嘧啶环的B系列化合物显示了一定的杀菌活性.

英文摘要：

On the basis of our previous work, in order to seeking for novel compounds with bioactivities to settle for the resistance problem, two series of novel pyrazole oxime ether derivatives have been designed and synthesized containing chlorothiazole group and pyrimidine rings applying the bioisosterism. Their structures were determined by 1^H NMR, IR, elemental analysis and MS, and their bioactivities were performed. Nearly half of the target compounds of series A with chlorothiazole group exhibited good insecticidal activity against culex pipiens pallens （100%, 5 mg.·L^-1）, several compounds of series A showed good activity against Aphis laburni Kaltenbach （100%, 200 mg/L） and Tetranychus cinnabarinus （100%, 200 mg/L）, and the compounds of series B with pyrimidine rings exhibited certain fungicidal activity.