中文摘要：

目的：了解血液病患者医院感染鲍氏不动杆菌耐药性，为临床预防治疗鲍氏不动杆菌感染与合理用药提供依据。方法收集2009年1月－2012年12月鲍氏不动杆菌临床分离株进行鉴定药敏，采用W HONT 5．6软件进行统计分析。结果4年中共分离鲍氏不动杆菌2442株，其中2009年分离出770株占31．5％、2010年602株占24．7％、2011年413株占16．9％、2012年657株占26．9％；4年鲍氏不动杆菌对β‐内酰胺类抗菌药物总耐药率，哌拉西林／他唑巴坦为10．7％、头孢他啶为14．0％、美罗培南为21．9％、头孢吡肟为21．9％、氨苄西林／舒巴坦为22．1％、亚胺培南为25．4％、哌拉西林为26．3％，对其他类抗菌药物的总耐药率以左氧氟沙星最低为3．0％，其次为环丙沙星8．8％、阿米卡星12．5％和妥布霉素16．3％。结论血液病患者医院感染分离菌中鲍氏不动杆菌占据重要地位，针对鲍氏不动杆菌耐药率，建议选择β‐内酰胺类药物时可选用含酶抑制剂的β‐内酰胺类抗菌药物的复合制剂，选择其他类抗菌药物时可选用左氧氟沙星。

英文摘要：

OBJECTIVE To investigate the drug resistance of Acinetobacter baumanii in patients with hematologic diseases and to provide experimental evidences for prevention and treatment of A .baumanii infection and rational drug use .METHODS Totally 2 442 clinical isolates from clinical patients between Jan .2009 and Dec .2012 were collected .The antimicrobial susceptibility was determined and the data were statistically analyzed with WHONT 5 .6 software .RESULTS Among the 2 442 A .baumanii strains isolated during the four years ,770 strains were isolated in the year 2009 （31 .5% ） ,602 strains in 2010 （24 .7% ） ,413 strains in 2011 （16 .9% ） ,657 strains in 2012 （26 .9% ） .The total resistance rates in four years for A .baumanii to β‐lactams ,including piperacillin/tazobactam ,ceftazidime , meropenem , cefepime , ampicillin/sulbactam , imipenem , piperacillin , were 10 .7% , 14 .0% ,21 .9% ,21 .9% ,22 .1% ,25 .4% ,26 .3% ,respectively .For other antibacterials ,the total resistance rate was the lowest to levofloxacin ,being 3 .0% ,followed by ciprofloxacin （8 .8% ） ,amikacin （12 .5% ） and tobramycin （16 .3% ） .CONCLUSION A .baumanii are important pathogenic bacteria isolated from patients with hematologic diseases . According to the drug‐resistant situation in our hospital , it is suggested that β‐lactam inhibitor compounds are the first choice to treat the infection by A .baumanii and levofloxacin is an alternative .