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中文摘要：
目的：探讨检测痰中核不均一核糖核蛋白A2/B1（heterogeneous nuclear ribonucleoprotein A2/B1,hnRNP A2/B1）在肺癌早期诊断中的意义。方法：收集63例疑诊肺癌患者的痰标本,分别采用痰涂片、痰细胞块切片细胞学检查（镜检找到癌细胞即诊断为肺癌）及痰细胞块切片免疫组织化学检测hnRNP A2/B1（表达阳性即诊断为肺癌）进行诊断,比较2种诊断方法的结果。结果：痰涂片及痰细胞块切片细胞学检查诊断肺癌的敏感度为31.8%,特异度为100%。痰细胞块检测hnRNP A2/B1诊断肺癌的敏感度为80%,特异度为68.4%。检测痰hnRNP A2/B1的敏感度显著高于痰细胞学检查（P〈0.01）。结论：痰细胞块结合免疫组织化学法检测hnRNP A2/B1有助于发现早期肺癌。
英文摘要：
Objective：To investigate the value of hnRNP A2/B1 expression in sputum for early diagnosis of lung cancer.Methods： A total of 63 sputum specimens of patients who were suspected as lung cancer were collected to compare the regular examination of sputum cells with detection of hnRNP A2/B1 by immunohistochemical staining method.Results： The sensitivity and specificity of regular examination of sputum cells were 31.8% and 100%,while the detection of hnRNP A2/B1 by immunohistochemical staining method were 80% and 68.4%.The detection of hnRNP A2/B1 was more effective by immunohistochemical staining method in diagnosis of lung cancer.Conclusions： Detection of hnRNP A2/B1 was valuable in early diagnosis of lung cancer.
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