中文摘要：

泛素特异性蛋白酶（USP）在调节蛋白酶体的活性、器官的发生、肿瘤的形成以及转录调控等方面都具有重要的作用。其中，USP9X通过去泛素化底物蛋白，影响肿瘤细胞增殖、黏附和信号转导，是肿瘤演进的重要因素之一。

英文摘要：

Ubiquitin specific peptidases play important roles in controlling proteasome activity, organo- genesis, tumorigenesis and transcriptional regulation. Ubiquitin specific peptidase 9X is able to remove ubiquitin from substrate proteins, so it may effectively regulate the proliferation, adhesion and signal transduction of tumor cells. It is a one of the most important factors in tumor progression.