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中文摘要：
免疫检查点分子是现在肿瘤免疫治疗讨论的热点。本文通过对免疫检查点T细胞免疫球蛋白粘蛋白3（Tim-3）的相关研究，从以下三个方面讨论它抑制肿瘤免疫的作用：第一，与不同的配体Gal-9、HMGB1、CEACAM-1结合来发挥作用；第二，可以负性调控CD4^＋T/CD8^＋T/NK等重要的免疫细胞；第三，针对Tim-3的抗肿瘤免疫治疗。表明Tim-3具有通过与不同配体的特异性结合，抑制固有免疫和适应性免疫细胞的能力，使肿瘤产生免疫逃逸。旨在阐述Tim-3免疫抑制的特异性，为免疫靶向治疗提供新思路和依据。
英文摘要：
The discovery of immune checkpoints has become an interesting topic in tumor immunotherapy area. This aticle discussed its function of tumor inhibition from three aspects through researches of immune checkpoint Tim-3. Firstly, play a role through combination of the different ligands. Secondly, negatively regulate the CD4^＋T/CD8^＋T/NK cells. Thirdly, immunotherapy Aimed at Tim-3. Declare that Tim-3 makes the contribution to tumor immune escape by specific binding with different ligands to the inhibitions both inherent immunity and adaptive immunity. This state of Tim-3 specificity of immunosuppressive is aimed at providing the new way and basis for tageted immunologic therapy.
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