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Spectroscopic Studies on the Interaction of Asiatic Acid with Bovine Serum Albumin
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 分类：O647.2[理学—物理化学;理学—化学] Q512.1[生物学—生物化学]
  • 作者机构：[1]Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Ministry of Education of China, Guilin, Guangxi 541004, China
  • 相关基金：Project supported by the National Natural Science Foundation of China （Nos. 20671023, 30460153, 21061002）, the Key Project of Chinese Ministry of Education （Nos. 03101, 204111）, Guangxi Natural Science Foundation of China （No. 2010GXNSFF013001）, and the Innovation Project of Guangxi Graduate Education （No. 2009106020703M42）.
作者： Yao, Di Ni, Shouhai Wen, Maogui Bian, Hedong Yu, Qing Liang, Hong Chen, Zhenfeng[1]
关键词： 牛血清白蛋白, 静电相互作用, 光谱学, 傅立叶变换红外光谱, 积雪, 荧光光谱, 拉曼光谱, BSA, bovine serum albumin, asiatic acid, secondary structure, fluorescence spectroscopy, fourier transforminfrared （FT-IR）, circular dichroism, raman spectroscopy
中文摘要：

荧光光谱学， Fourier 变换红外线(英尺红外) 光谱学，圆形的二色性(CD ) 和 FT-Raman 光谱学被采用在模拟生理的条件下面分析 asiatic 酸(AA ) 的绑定到牛的浆液白朊(BSA ) 。荧光数据表明由 AA BSA 熄灭的荧光是 BSA-AA 建筑群的形成的结果。由 AA 熄灭 BSA 的机制的荧光是一个静态的熄灭过程。根据 Vant Hoff 方程，热力学的参数热含量变化(H0 ) 和为反应的熵变化(S0 ) 被评估是 ? 在 0.106.0 U 的范围的 12.55 kJthe PPO 活动

英文摘要：

Fluorescence spectroscopy, Fourier transform infrared （FT-IR） spectroscopy, circular dichroism （CD） and FT-Raman spectroscopy were employed to analyze the binding of the asiatic acid （AA） to bovine serum albumin （BSA） under simulative physiological conditions. Fluorescence data revealed that the fluorescence quenching of BSA by AA was the result of the formation of BSA-AA complex. The fluorescence quenching mechanism of BSA by AA was a static quenching procedure. According to the Van＇t Hoff equation, the thermodynamic parameters enthalpy change （△H0） and entropy change （△S0） for the reaction were evaluated to be --12.55 kJ·mol^-1 and 67.08 kJomol 1, respectively, indicating that hydrophobic and electrostatic interactions played a major role in stabilizing the complex. The influence of AA on the conformation of BSA has also been analyzed on the basis of FT-IR, CD and FT-Raman spectra.

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期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175