中文摘要：

Survivin， apoptosis 家庭蛋白质的禁止者的一个成员，为肿瘤房间生存能力在肿瘤房间和它的重要角色由于它的选择表示在癌症成为了一个吸引人的治疗学的目标。这里，我们在前列腺癌症房间显示出那基于向量的小介入 RNA (siRNAs ) silenced survivin 表情，导致显著地减少了房间增长并且提高了 apoptosis，并且增加了前列腺癌症房间(PC-3 ) 的敏感到导致 apoptosis 代理人， platinol。而且，有表示 siRNA 向量的 PC-3 房间 transfected 在 vivo 在裸体老鼠异种皮移植显示出更低的肿瘤形成。这些结果证明由 siRNA 的 survivin 表示的抑制稀释了前列腺癌症房间的恶意的显型，并且可以为雄激素无关的前列腺癌症的基因治疗提供一条新奇途径。

英文摘要：

Survivin, a member of inhibitor of apoptosis family protein, has become an attractive therapeutic target in cancer due to its selective expression in tumor cells and its important roles for tumor cell viability. Here, we show that vector-based small interfering RNAs （siRNAs） silenced survivin expression in prostate cancer cells, resulting in significantly reduced cell proliferation and enhanced apoptosis, and increased the sensitivity of prostate cancer cells （PC-3） to the apoptosis-inducing agent, platinol. Furthermore, PC-3 cells transfected with the siRNA-expressing vector showed lower tumor formation in nude mice xenografts in vivo. These results demonstrated that inhibition of survivin expression by siRNA attenuated the malignant phenotypes of prostate cancer cells, and may provide a novel approach for gene therapy of androgen-independent prostate cancer.