中文摘要：

目的从神经电生理学的角度揭示SO2对中枢神经系统的毒性作用。方法采用SO2动式吸入染毒技术使雄性SD大鼠染毒7天,每天6h,SO2的染毒剂量为28mg/m3。用电生理学玻璃微电极细胞外记录的方法,在体观察SO2吸入对大鼠海马CAI区神经元自发放电活动的影响,并通过建立被动回避行为条件反射对大鼠的学习和记忆能力进行测试。结果SO2染毒使大鼠海马CAI区神经元自发放电的时程较对照组显著延长（P〈0.001）;神经元的平均放电频率显著降低,主要表现为中频放电神经元比例明显下降（P〈0.05）,而低频放电神经元比例升高;SO2染毒大鼠的学习记忆能力显著下降（P〈0.05,P〈0.01）。结论SO2具有类似神经毒物作用,可显著抑制大鼠海马CAI区神经元的兴奋性,并干扰和影响学习记忆功能。

英文摘要：

Objective To study the toxicological mechanism of SO2 on central neural system by electropbysiological method. Methods Male SD rats were housed in exposure chambers and treated at the concentration of 2gmg/m3 SO2 for 7 days （6h/d）, while control rats were treated with filtered air in the same condition. Using glass micro-electrodes recording in vivo, the frequencies and numbers of spontaneous discharge in hippoeampal CAI neurons were measured. Influences of the learning and memory functions were measured by setting up passive avoidance behavior reflex. Results SO2 decreased significantly the neurons spontaneous discharge frequency and prolonged the neurons spontaneous period in hippocampal CAI. SO： significantly decreased the learning and memory function of rats. Conclusion The results indicated that S02 could be a neurotoxin. It could inhibit the hippocampal neurons excitability and affect the learning and memory function of rats.