中文摘要：

蛋白质酪氨酸硝基化是一种重要的蛋白质翻译后修饰，与多种病症相关。经由过氧亚硝酸根（ONOO-）和NO2^-／H2O2／血红素过氧化物酶体系是促使蛋白质硝化最主要的两种途径，其反应为自由基机理。本文对体内蛋白质硝基化的途径、机制及其生物学意义作了综述，指出蛋白质的硝化具有选择性，特定酪氨酸残基发生硝化能够改变蛋白质的结构和功能，影响其免疫应答和可能涉及的信号转导过程，从而具有重要的生物学意义。

英文摘要：

Protein tyrosine nitration is an important posttranslational modification involving a variety of diseases. It＇s occurred via peroxynitrite or nitrite/hydrogen peroxide/hemeperoxydase system, and nitrotyrosine is formed by free radical reaction. The in vivo protein nitration pathways, the mechanism and that protein nitration has selectivity, and nitration of special tyrosine and functions of the protein, and affect the immunological response the biological significance are discussed. It points out residue（s） can lead to the alteration of the structure or signal transduction involved.