中文摘要：

血管内皮生长因子（VEGF）及血管内皮生长因子受体-2（VEGFR-2）是调节血管生成、内皮细胞增殖和迁移等的关键调控因子。通过阻断VEGF与VEGFR-2的结合可抑制新生血管形成，而新生血管的形成是肿瘤生长和转移的基础。介绍VEGF／VEGFR-2在血管形成中的作用，以及具有抗肿瘤作用的靶向VEGF／VEGFR-2的血管生成抑制剂的研究近况。

英文摘要：

Vascular endothelial growth factor （VEGF） and its tyrosine kinase receptor -- VEGFR-2 play the critical roles in modulating angiogenesis, as well as the proliferation and migration of endotbelium. Angiogenesis is a basis of tumor growth and metastasis. It is expected that blocking the interaction of VEGF and VEGFR-2 will be an efficient anticancer therapeutic approach. This review summarizes VEGF/ VEGFR-2 signaling related to angiogenesis, and the development of VEGF/VEGFR-2 inhibitors, including biomacromolecules and micromolecules.