中文摘要：

目的：[^18F]标记表皮生长因子受体酪氨酸激酶抑制剂（EGFR—TKI）正电子显像剂在指导肿瘤分子靶向治疗中具有非常重要的作用。本文目的是找到一种全自动、适合日常使用的[^18F]标记EGFR-TKI正电子显像剂的全自动合成方法。方法：采用一步法合成[^18F]EGFR-TKIPET显像剂。首先合成4-[^18F]氟苯胺基，然后合成4-[^18F]氟苯胺基-6,7-二甲氧基喹唑啉。结果：整个合成过程大约60分钟，产率25％．35％（未校正），放化纯度〉95％。结论：本文建立了一种适合临床日常应用的[^18F]EGFR-TKIPET显像剂的全自动合成方法。该方法对于进一步开发新型[^18F]标记的表皮生长因子受体抑制剂PET显像具有重要价值。

英文摘要：

ABSTRACT Objective： [^18F]-labelled tyrosine kinase inhibitor of epidermal growth factor receptor is often used for guidance on treatment of EGFR overexpressed cancer. Our objective is to develop a fully automatic method of routine production of [^18F]-labelled EGFR-TKI. Methods： A new one-pot method is used. The first step is synthesis of 4- [^18F] fluoroaniline, then 4- [^18F] fluorine based 6, 7- dimethoxy-anilinoquinazoline. Results： The total radiosynthesis time is 70 minutes after EOB. The radiochemical yield is 25%-35% （decay uncorrected）, and the radiochemical purity is more than 95%. Conclusion： The one-pot automatic synthesis of [^18F] labelled tyrosine kinase inhibitor of epidermal growth factor receptor is promising for routine use. Key words： [^18F]; EGFR-TKI; PET; Automatic synthesis