中文摘要：

目的：了解外源性注意和内源性注意是否可以分离？内源性注意与哪些生理位置相关？方法：用机械毁损法毁损大鼠双侧MT,观察大鼠行为和注意能力变化。同时,电击被毁损后大鼠右侧VTA,用免疫组织化学法,采取同脑左右对比,观察大鼠相关脑区的c-fos表达,了解在毁损发生后信息的传导情况。结果：大鼠在双侧MT被机械毁损之后,3天里持续的注意能力变化与麻醉时基本相同,内源性注意完全消失;强烈的痛刺激有反应,角膜、吞咽反射存在、外源性注意存在,且这种状态呈现出不可恢复的形势。未毁损MT时,电击右侧VTA,同脑左右侧表现出有显著差异的c-fos表达;毁损双侧MT后电击右侧VTA,同脑左右侧c-fos表达基本上无差异。结论：毁损MT大鼠内源性注意消失,外源性注意依然存在,外源性注意和内源性注意可以分离。从c-fos表达上可以看出,毁损MT后电击信号没有传入大鼠脑的相应部位,这可能是导致大鼠内源性注意消失的主要原因,由此推知双侧MT是大鼠内源性注意通路上的关键位置。

英文摘要：

The methods of mechanical lesion were used to cut the rat＇s two sides of mamillotegmental tract（MT） in order to know how to change it＇s behavior and attention ability.In the mean time,the methods of electric shock with immunocytochemistry were used to the rat＇s right ventral tegmental area（VTA） for the comparison of right and left.The result indicated that the rat could be kept out of endogenous attention and the exogenous attention could remain.The state was the same with anaesthesia and couldn＇t be recovery.It was implied that the methods of mechanical lesion could make rats keep out of endogenous attention,but the effects of exogenous attention remained.Endogenous attention and exogenous attention could be separated.Fos expression showed that the massage couldn＇t be transmited to CNS when MT was cut.Maybe it＇s the main reason for rats to be out of endogenous attention.