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“十八反”甘草与甘遂、芫花、大戟反药配伍的方剂特点分析

ISSN号：1673-1727
期刊名称：《中华中医药杂志》
时间：0
分类：R285.1[医药卫生—中药学;医药卫生—中医学]
作者机构：[1]南京中医药大学基础医学院,南京210046, [2]江苏省方剂研究重点实验室,南京210046, [3]南京中医药大学中医药文献研究所,南京210046
相关基金：国家重点基础研究发展计划（973计划）（No.2011CB505300-01）; 江苏高校优势学科建设工程资助项目（No.PAPD）

作者：杨环[1,2], 范欣生[1,2], 尚尔鑫[2], 李芸[2,3], 卞雅莉[1,3], 蒋辰雪[1,2]

关键词：十八反, 古方, 甘草, 甘遂, 芫花, 大戟, 数据挖掘, Eighteen incompatible pairs of drugs, Ancient formulae, Radix Glycyrrhizae, Radix Euphorbiae Pekinensis, Flos Genkwa and Radix Kansui, Data mining

中文摘要：

目的：运用关联规则和对应分析等方法,分析含＂十八反＂甘草与甘遂、芫花、大戟古方的配伍药物、剂型、年代、用法、组方药味数目等特点。方法：采用PASW18进行数据统计和处理,用关联规则和对应分析等数据挖掘方法进行分析研究。结果：甘草与逐水药反药同方在配伍方面,较为重视与温阳、化痰、理血等药的配合,以肉桂、干姜、细辛、半夏、当归、大黄、川芎等药为主。剂型涉及膏、丸、汤、散等8种;唐代多用汤剂,宋代多用散剂,清代均为膏剂;用法明清以前内服为主,清代主要为外用膏剂。结论：＂十八反＂甘草与逐水药同方配伍高频药物以温阳、化痰、理血等功效为主;剂型以膏最多,丸、汤次之;用法方面外用多于内服。

英文摘要：

Objective： To analyze the ancient formulae which contain both TCM herbs for dispelling retained water （composed of Radix Euphorbiae Pekinensis, Fits Genkwa and Radix Kansuiin, according to the Dictionary of TCM Formulae） and Radix Glycyrrhizae, and to investigate their characteristics of compatibility, preparation, age, usage and drug numbers. Methods： Materials and data were processed and analyzed by PASW18. Data mining methods, such as association rules and correspondence analysis were applied. Results： TCM drugs for warming yang, resolving phlegm and activating blood circulation were found to be frequently combined with Radix Glycyrrhizae and TCM herbs for dispelling retained water in the formulae, especially Cortex Cinnamomi, Rhizoma Zingiberis, Radix et Rhizoma Asari, Rhizoma Pinelliae, Radix Angelicae Sinensis, Radix et Rhizoma Rhei and Rhizoma Chuanxiong. There were 8 preparations, including plaster, pill, decoction, powder, and so on. The decoction was mainly used in Tang Dynasty, powder in Song Dynasty, and piaster in Qing Dynasty. Formulae for oral administration were used before Ming Dynasty and Qing Dynasty. Formulae for external application were all used in Qing Dynasty. Conclusion： The abovementioned studies indicated that formulae containing Radix Glycyrrhizae and TCM Herbs for dispelling retained water, which were listed in the 18 incompatible pairs of drugs, were frequently combined with TCM drugs for warming yang, resolving phlegm and activating blood circulation. Formulae for external application were used more than those for oral administration.

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