中文摘要：

目的：探讨红藤煎剂对盆腔炎模型大鼠子宫内膜容受性的可能作用机制。方法：采用输卵管注射苯酚糊剂建立盆腔炎模型,实验随机分为正常对照组、模型对照组、西药对照组（庆大霉素组）、中药对照组（康妇消炎栓组）及红藤煎剂灌胃组、灌肠组,每组10只。各组给予相应处理30 d后,RT-PCR法检测各组大鼠子宫内膜HOXA10 mRNA表达,Western blot法检测HOXA10蛋白表达。结果：与正常组比较,模型组大鼠子宫内膜HOXA10 mRNA及蛋白表达明显降低（P〈0.05）;各药物组两者表达均明显升高,其中红藤煎剂灌肠组升高最显著,与其他药物组比较,差异具有统计学意义（P〈0.05）;与正常对照组比较,差异无统计学意义（P〉0.05）。结论：红藤煎剂能够提高子宫内膜HOXA10的表达,从而改善妊娠结局,灌肠治疗效果更显著。

英文摘要：

Objective： To discuss the mechanism of Hongteng Decoction on endometrial receptivity of rats with pelvic inflammation. Methods： Models with pelvic inflammation were built by injecting phenol paste into rats＇ fallopian tubes,and experiment was divide into normal,model,western medicine control,Chinese medicine control and Hongteng Decoction intragastric or enema groups,each group with 10 rats. Every group was given the corresponding medicine or saline for 30 days,then the the expression of endometrium HOXA10 mRNA and protein in model group were determined respectively by RT- PCR and Western blot. Results： To compare with normal group,the expression of endometrium HOXA10 mRNA and protein in model group were decreased obviously（ P〈0. 05）,that were increased in the other medicine groups,the effect of Hongteng Decoction enema group was the most significant,the differences between the other groups were significant（ P〈005）. Conclusion： Hongteng Decoction can increase endometrium HOXA10 mRNA and protein expression,and improve the clinical pregnancy rate; the effect of Hongteng Decoction enema group was the best.