白血病来源的树突状细胞(DC)具有抗原提呈功能,又携带白血病相关抗原,能激发机体免疫系统产生特异性细胞毒性T细胞,对白血病细胞进行杀伤。以白血病细胞来源DC为基础的免疫疗法为控制和清除残留白血病细胞,从而提高白血病的治愈率提供了良好前景。
Dendritic cells(DCs) are potent antigen presenting cells that play a prominent role in the development of T cell immune responses. The expression of tumor- associated and :leukemic- associated antigens by leukemia-DCs, and the activation of autologous anti-leukemic T cells have been shown by several groups. Vaccination with leukemic-DCs has been suggested as a novel treatment option for leukemic patients to eliminate residual leukemia cells.