中文摘要：

克里米亚半岛刚果的出血性的发烧病毒(CCHFV ) 在人是有多达 50% 的命运率的一个高度病原的滴答响忍受病毒。CCHFV 广泛地在全世界在国家被散布。在人的 CCHFV 感染的爆发在 Xinjiang 省发生在优先的年里，中国。流行病学的调查检测了 CCHFV RNA 在滴答响并且动物；然而，很少孤立被识别。在这研究，我们鉴别 asiaticum 滴答响并且从 Hyalomma asiaticum 孤立一个新 CCHFV 种类从在 Xinjiang 的 Tarim 盆的北方镇定，中国。感染和 CCHFV 的抗原表示的初步的调查在新生的鼠标被执行。为在新生的老鼠的 CCHFV 复制的目标纸巾被识别。与另外的中国种类的种系发生的关系的分析建议 CCHFV 的多样的遗传型多年在 Xinjiang 传播了。这些调查结果为本地居民提供重要卓见进我们 CCHFV 感染和进化以及疾病预防和控制的理解。

英文摘要：

Crimean-Congo hemorrhagic fever virus （CCHFV） is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents.