中文摘要：

金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请，担心大。与为液体运输的新奇解剖、组织学的结构的发现，然而，内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习，在腱，容器，和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方，我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5， 15，和 30 min 并且在 1， 4， 12，和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果：在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的；在肺，心，和肠是类似的；并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快，直接并且发行量无关的 AuNP 器官运输小径，它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且，这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution，它可以导致新奇、有效治疗学并且管理策略。

英文摘要：

The biodistribution of gold nanoparticles （AuNPs） is closely related to toxicological effects and is of great concern because of their potential application in diverse biomedical areas. However, with the discovery of novel anatomic and histological structures for fluid transport, the underlying mechanisms involved in the in vivo transport and biodistribution of AuNPs require further in-depth investigations. In the current study, we investigated the biodistribution of 10-nm AuNPs in rats after intervaginal space injection （ISI） in the tarsal tunnel, where a focal point of tendons, vessels, and nerve fibers may optimally connect to other remote connective tissues. The intravenous injection （IVI） of AuNPs served as a control. The blood and organs were collected at 5, 15, and 30 min and at 1, 4, 12, and 24 h after injection for quantitative analysis of Au distribution with inductively coupled plasma mass spectrometry （ICP-MS）. IVI and ISI yielded significantly different results： The AuNP content in the blood after ISI was much lower than that after IVI; was similar in the lungs, heart, and intestines; and was higher in the skin and muscle. These findings were supported by the ratios of AuNP content and relative organ AuNP distribution proportions. Our results demonstrated a fast, direct, and the circulation-independent AuNP-organ transport pathway, which may improve our understanding of physiological and pathological biodistribution processes in biological systems. Furthermore, these results provide novel insights into the in vivo transport and biodistribution of AuNPs, which may lead to novel and efficient therapeutic and administration strategies.