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In Vitro Bactericidal Activity of Jinghua Weikang Capsule （荆花胃康胶丸） and Its Individual Herb Chenopodium Ambrosioides L. against Antibiotic-Resistant Helicobacter Pylori

ISSN号：1009-6094
期刊名称：《安全与环境学报》
时间：0
分类：S852.63[农业科学—基础兽医学;农业科学—兽医学;农业科学—畜牧兽医] X832[环境科学与工程—环境工程]
作者机构：[1]Department of Tradional Chinese Medicine and Integrated Tradional Chinese and Western Medicine, Peking University First Hospital, Beijing (100034), China, [2]Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing (100029), China, [3]Department of Gastroenterology, Peking University First Hospital, Beijing (100034), China
相关基金：The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg 2012 Supported by Capital Medical Development and Research Foundation （No. SF-2007-Ⅲ-01） and National Natural Science Foundation of China （No. 8107295）;

作者：刘伟[1], 刘宇[2], 张学智[1], 李宁[1], 成虹[3]

关键词：抗生素耐药性, 幽门螺旋杆菌, 体外抗菌活性, 抗药性, 胶囊, 荆芥, 胃, 液体培养基, Helicobacter pylori, Jinghua Weikang Capsule, Chenopodium ambrosioides L., antibiotic-resistance, bactericidal activity, Chinese medicine

中文摘要：

Objective:To investigate the bactericidal effects of Jinghua Weikang Capsule(荆花胃良胶丸and its major component Chenopodium ambrosioides L.on antibiotic-resistant Helicobacter pylori.Methods: Four clinical antibiotic-resistant H.pylori strains were isolated and incubated in liquid medium containing Jinghua Weikang Capsule or Chenopodium ambrosioides L By means of time-kill curve method,the average colony counts and bactericidal rate were calculated at time points of 0,4,8 and 24 h after the incubation and the time-kill curves were charted.Results:Both Jinghua Weikang Capsule and Chenopodium ambrosioides L at a concentration of 0.64 g/L showed obvious bactericidal effect against antibiotic-resistant H.pylori after 4 h of incubation.Conclusion:Jinghua Weikang Capsule and Chenopodium ambrosioides L.are considered to be active against antibiotic-resistant H.pylori in vitro.

英文摘要：

Objective： To investigate the bactericidal effects of Jinghua Weikang Capsule （荆花胃康胶丸） and its major component Chenopodium ambrosioides L. on antibiotic-resistant Helicobacter pylori. Methods： Four clinical antibiotic-resistant H. pylori strains were isolated and incubated in liquid medium containing Jinghua Weikang Capsule or Chenopodium ambrosioides L. By means of time-kill curve method, the average colony counts and bactericidal rate were calculated at time points of 0, 4, 8 and 24 h after the incubation and the time-kill curves were charted. Results： Both Jinghua Weikang Capsule and Chenopodium ambrosioides L. at a concentration of 0.64 g/L showed obvious bactericidal effect against antibiotic-resistant H. pylori after 4 h of incubation. Conclusion： Jinghua Weikang Capsule and Chenopodium ambrosioides L. are considered to be active against antibiotic-resistant H. pylori in vitro.

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