中文摘要：

探索了N,O-缩醛7 C-2位的不对称烯丙基化的条件,建立了路易斯酸催化条件下高选择性烯丙基化方法（产率73%,dr 94∶6）.并以此为关键反应,合成了制备（-）-Epiquinamide（1）的关键中间体21.作为延续性工作,建立了一条由（2S,3S）和（2S,3R）-9差向异构体混合物制备光学纯（＋）-Febrifugine（3）的方法.从而开发了一条以廉价谷氨酸为原料制备克级常山碱的可能途径.

英文摘要：

Lewis acid catalyzed asymmetric allylation ofN, O-acetal 7 with allyltrimethylsilane was developed for the synthe- sis of compounds 9, 10 and 16 with high disasterselectivities. A key middle compound 21 for synthesis of （--）-epiquinamide （1） was easily prepared from allylation product 16. In continuation of our work, a convenient method for synthesis of （＋）-febrifugine （3） was also described from the mixture of （2S,3S） and （2S,3R）-9. Therefore, a possible approach for gram scale preparation of （＋）-febrifugine （3） from glutamic acid was achieved.