中文摘要：

在中间人的最近的开发新陈代谢的研究给我们看我们中间人新陈代谢的理解不对结束将近近平。Acetylation 作为为新陈代谢的主要规章的机制新兴，加入 transcriptional 规定，反馈抑制， allosteric 规定和 phosphorylation 的著名机制。直接、间接的证据证明了新陈代谢的酶的 acetylation 引起各种各样的变化，从禁止并且激活到影响蛋白质稳定性的催化活动。Acetylation 可以也在在小径之中在一条小径，或新陈代谢的流动以内协调酶活动起一个通用作用。另一发现那把中间人新陈代谢放进焦点是某些代谢物在房间发信号起不可缺少的作用。在伪 - ketoglutarate 的 2-hydroxylglutarate 或减少的失衡的累积显著地影响称为 dioxygenases 的蛋白质的一个家庭，改变肿瘤相关的组织缺氧可诱导的因素小径，并且是可能在 histone 包含了 methylation。这些新观察在科学界提起了宽广兴趣，由于在新陈代谢和人的疾病之间的靠近的连接。

英文摘要：

Recent developments in intermediary metabolic research show us that our understanding of intermediary metabolism is not even nearly close to completion. Acetylation is emerging as a major regulatory mechanism for metabolism, joining the well-known mechanisms of transcriptional regulation, feedback inhibition, allosteric regulation and phosphorylation. Direct and indirect evidence has shown that acetylation of metabolic enzymes causes various changes, ranging from inhibiting and activating catalytic activity to affecting protein stability. Acetylation may also play a universal role in coordinating enzyme activity within a pathway, or metabolic flux among pathways. Another finding that has put intermediary metabolism into focus is that certain metabolites play indispensable roles in cell signaling. Unbalanced accumulation of 2-hydroxylglutarate or decrease in a-ketoglutarate significantly affects a family of proteins called dioxygenases, alters tumor-related hypoxia-inducible factor pathways, and is possibly involved in histone methylation. These new observations have raised broad interest in the scientific community, due to the close connections between metabolism and human diseases.