中文摘要：

目的调查水源性高碘地区6—12岁儿童的水碘、尿碘及甲状腺容积，了解甲状腺容积与水碘、尿碘含量及年龄之间的关系。方法2011年7月至2012年3月，在山东、山西、河北、河南4个省，将水碘划分为50-99、100-149、150-299、≥300“以4个水平，每个水碘水平选择3个村作为调查村；在调查村的村小学采集全部6～12岁儿童所在家庭的食用盐检测盐碘；剔除食用盐为碘盐的儿童，检测剩余儿童饮水碘含量。并进行甲状腺容积和尿碘测定。分析甲状腺容积与水碘、尿碘及年龄之间的关系。盐碘检测采用半定量法，尿碘检测采用砷铈催化分光光度法，甲状腺容积检测采用B超法。结果6—12岁各年龄组儿童甲状腺容积的中位数分别为2．00、2．21、2．54、2．94、3．30、3．44、3．72ml；尿碘中位数分别为252．3、319．4、345．2、350．9、371．2、384．4、409．6μg／L。水碘〉100μg／L时，除水碘100-149μg／L组6岁儿童尿碘中位数为274．0μg／L外，其余各年龄组儿童尿碘中位数均〉300μg／L。水碘、尿碘、年龄均与甲状腺容积呈正相关[相关系数（r）=0．154、0．148、0．381，P均〈0．01]；水碘与尿碘呈明显正相关（r=0．399，P〈0．05）。同一水碘水平，不同年龄儿童的尿碘和甲状腺容积，随年龄增加而越来越分散，表现出对高碘的个体化反应差异。结论在水源性高碘地区，尽管食用不加碘食盐，仍有儿童处于碘过量的状态，甲状腺容积与水碘、尿碘有关。

英文摘要：

Objective To detect water iodine content, urinary iodine content and thyroid volume of children aged 6 - 12 in high water-iodine areas and to explore the relationship between thyroid volume and the three factors （water iodine content, urinary iodine content and age）. Methods In July 2011 to March 2012, four provinces of Shandong, Shanxi, Henan and Hebei were investigated, and water iodine content were divided into 4 levels, which were 50 - 99, 100 - 149, 150 - 299, and ≥300 μg/L, respectively. For each water iodine content level, three villages were analyzed. School children aged 6 - 12 were recruited, family salt iodine was determined to exclude those children who had intaken iodized salt. After that, water iodine content, urinary iodine content and thyroid volume of children were measured. Finally, relationships between thyroid volume and water iodine content, urinary iodine content and age were analyzed. Salt iodine was detected by semi-quantitative method; urinary iodine was detected by arsenic cerium catalytic spectrophotometry; thyroid volume was detected by B-scan uhrasonography. Results The medians of thyroid volume in each age group from 6 to 12 years were 2.00, 2.21, 2.54, 2.94, 3.30, 3.44, and 3.72 ml, respectively; the medians of urinary iodine content in each age group were 252.3, 319.4, 345.2, 350.9, 371.2, 384.4, and 409.6 μg/L, respectively. Under the condition of water iodine content 〉 100 μg/L, the median of urinary iodine content of children aged 6 in 100 - 149 μg/L water iodine content group was 274.0 μg/L, while other groups with different ages got the median of urinary iodine content more than 300 μg/L. Water iodine content, urinary iodine content and age were all positively correlated with thyroid volume （r = 0.154, 0.148, 0.381, all P 〈 0.01）. In addition, water iodine content and urinary iodine content were positively correlated （r = 0.399, P 〈 0.05）. With the same water iodine content level, the urinary iodine content and thyroid volume showed a significant disp