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中文摘要：
砷是一种生物活性元素。长期接触砷会导致癌症、心脏病、糖尿病等疾病的发生。无机砷甲基化是砷在动物体内的主要代谢方式，被公认为砷元素的解毒过程，因此无机砷甲基化的研究引起了科学家们的广泛关注并取得了重要进展。本文综述了近年来国内外学者及作者研究组在“砷甲基化酶”，“无机砷甲基化机制”及“无机砷甲基化抑制”等方面的研究进展。
英文摘要：
Arsenic is a bioactive element. Throughout the world, millions of people are at risk of cancer, heart disease, and diabetes because of chronic arsenic exposure. The methylation of inorganic arsenic （iAs） attract abroad attention since it is the main metabolism pathway in mammals and has been commonly considered as a detoxification mechanism. This dissertation summarizes the recent research advancement of ＂arsenic （＋3） methyltransferase＂, ＂the mechanism of arsenite methylation＂ and ＂the inhibition of arsenite methylation＂.
同期刊论文项目
同项目期刊论文
Rapid Equilibrium Kinetic Analysis of Arsenite Methylation Catalyzed by Recombinant Human Arsenic (+
Azole derivatives as novel non-iron-chelating inhibitors of prolyl hydroxylase 3 for HIF-1 activatio
A potent antitumor Zn2+ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, inter
A versatile water soluble fluorescent probe for ratiometric sensing of Hg2+ and bovine serum albumin
Coordination-Induced Assembly of Coordination Polymer Submicrospheres: Promising Antibacterial and i
Functional evaluation of Asp76, 84, 102 and 150 in human arsenic(III) methyltransferase (hAS3MT) int
Residues in human arsenic (+3 oxidation state) methyltransferase forming potentail hydrogen bond net
Evidence for inhibition of HIF-1 alpha prolyl hydroxylase 3 activity by four biologically active tet
A Zn2+-specific turn-on fluorescent probe for ratiometric sensing of pyrophosphate in both water and
Development of a chemiluminescent imaging assay for the detection of anti-erythropoietin antibody in
Subcellular distribution of rare earth elements and characterization of their binding species in a n
Application of atmospheric pressure dielectric barrier discharge plasma for the determination of Se,
Atomization of hydride with a low-temperature, atmospheric pressure dielectric barrier discharge and
Polyol-mediated synthesis and luminescence of lanthanide-doped NaYF4 nanocrystal upconversion phosph
Determination of Se, Pb, and Sb by atomic fluorescence spectrometry using a new flameless, dielectri
Quantification of selenium-tagged proteins in human plasma using species-unspecific isotope dilution
Modeling persistent organic pollutant (POP) partitioning between tree bark and air and its applicati
Alternative thermodiffusion interface for simultaneous speciation of m organic and inorganic lead an
Synergistic defensive mechanism of phytochelatins and antioxidative enzymes in Brassica chinensis L.
Evaluation of a hydride generation-atomic fluorescence system for the determination of arsenic using
Strategy for absolute quantification of proteins: CH3Hg+ labeling integrated molecular and elemental
Different alkyl dimethacrylate mediated stearyl methacrylate monoliths for improving separation effi
Development of a sensitive gas sensor by trapping the analytes on nanomaterials and in situ catalumi
Real-time monitoring of chemical reactions by mass spectrometry utilizing a low-temperature plasma p
A New Strategy for Highly Sensitive Immunoassay Based on Single-Particle Mode Detection by Inductive
Discrimination and Identification of Flavors with Catalytic Nanomaterial-Based Optical Chemosensor A
Morphology- and phase-controlled synthesis of monodisperse lanthanide-doped NaGdF4 nanocrystals with
A simple and fast detection technique for arsenic speciation based on high-efficiency photooxidation
Direct detection of explosives on solid surfaces by low temperature plasma desorption mass spectrome
Determination of bismuth in solid samples by hydride generation atomic fluorescence spectrometry wit
Rapid screening of active ingredients in drugs by mass spectrometry with low-temperature plasma prob
The determination of low-molecular-mass thiols with 4-(hydroxymercuric)benzoic acid as a tag using H
Vapour generation at a UV/TiO2 photocatalysis reaction device for determination and speciation of me
SEC-ICP-MS and ESI-MS/MS for analyzing in vitro and in vivo Cd-phytochelatin complexes in a Cd-hyper
Pulsed large volume injection gas chromatography coupled with electron-capture negative ionization q
A new vapor generation system for mercury species based on the UV irradiation of mercaptoethanol use
Determination of cadmium in seawater by vapor generation atomic fluorescence spectrometry after onli
On-line preconcentration with a novel alkyl phosphinic acid extraction resin coupled with inductivel
Direct detection of explosives on solid surfaces by mass spectrometry with an ambient ion source bas
Synthesis and characterization of efficient near-infrared upconversion Yb and Tm codoped NaYF4 nanoc
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