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中文摘要：
膜蛋白参与细胞中的各项生命活动,具有复杂而特殊的生理功能,同时它也是重要的药物标靶,因此研究膜蛋白的结构及功能对于保持人类健康和治疗疾病具有重要的意义.α-螺旋跨膜蛋白是生物体内最为重要和广泛的一类膜蛋白,本文综述了α-螺旋跨膜蛋白在折叠和自组装特性上的最新研究进展,总结了跨膜过程中的两阶段模型;详细介绍了α-螺旋跨膜蛋白的跨膜性质及其跨膜的影响因素,包括跨膜序列的长度和疏水性、疏水性错配和界面锚固、极性残基和脯氨酸等;进一步总结了α-螺旋跨膜蛋白通过跨膜螺旋相互作用形成高度有序自组装体的结构基础;并介绍了研究α-螺旋跨膜蛋白折叠和自组装常用的化学和生物学方法,希望能为进一步开展该领域研究提供参考。
英文摘要：
Given the critical roles of membrane proteins in cellular processes ranging from signal transduction to immune response,as well as the significance of these proteins as drug targets,efforts to understand their structures and functions are vital for human health and diseases.α-Helix transmembrane protein is a significant and common membrane protein.This paper reviews the recent progress of its folding and self-assembly,presenting an overview of the two-stage model and structural bases for transmembrane association and introducing the novel chemical and biological method for the studies of folding and self-assembly of α-helix transmembrane protein.
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