中文摘要：

目的采用Meta分析评价SLCO1B1 T521C基因多态性与他汀类药物药代动力学参数的关系。方法计算机检索Pubmed、EMBASE、Cochrane Library、中国生物医学文献数据库、中国期刊全文数据库、万方、维普数据库,收集有关SLCO1B1 T521C基因多态性和他汀类药物药代动力学关系的研究。提取AUC（0-6 h）、AUC（0-12 h）、AUC（0-24 h）、AUC（0-inf）、C（max）和CL/F等药代动力学参数。用标准均数差（SMD）和95%CI比较野生型（TT）基因型和突变基因型（TC、CC、TC＋CC）。亚组分析根据种族人群、他汀类药物的类型进行。用敏感性分析对各项研究进行异质性检验。用RevMan 5.3软件对符合纳入标准的研究进行Meta分析。结果共纳入25篇文献903例病例,Meta分析结果显示：全部研究的AUC（0-inf）标准均数差TT-TC为0.51（95%CI：0.29-0.72）,TT-CC为1.80（95%CI：1.31-2.29）,TT-（TC＋CC）为0.78（95%CI：0.57-0.99）;突变基因型的AUC（0-inf）的标准均数差较高。在白种人和亚洲人的亚组分析得出同样的结果。全部研究的C（max）标准均数差TT-TC为0.48（95%CI：0.18-0.77）,TT-CC为1.24（95%CI：0.77-1.70）,TT-（TC＋CC）为0.65（95%CI：0.43-0.87）;突变基因型的C（max）的标准均数差也较高。在白种人和亚洲人的亚组分析也得出同样的结果。全部研究的CL/F标准均数差TT-TC为-1.01（95%CI：-1.91～-0.11）,TT-CC为-1.51（95%CI：-2.08～-0.94）,TT-（TC＋CC）为-1.07（95%CI：-1.55～-0.59）,突变基因型的CL/F的标准均数差较低。结论 SLCO1B1T521C等位基因可能对他汀类药物药代动力学起着重要影响。

英文摘要：

Objective To evaluate the influence of SLCO1B1 gene T521C polymorphisms on the pharmacokinetics of statins. Methods We searched PubMed, EMBASE, Cochrane Library, CBM, CNKI, WANFANG, and VIP databases for studies that investigated the influence of SLCO1B1 gene T521C polymorphisms on pharmaeokinetics of statins. The pharmacokinetic parameters including the areas under the concentration-time curves following statin administration （ AUC0-6 h, AUC0 -12 h, AUC0-24 h, and AUC0_inf） , the maximum plasma drug concentration （Cmax） and oral clearance （CL/F） were extracted from the included studies. The standardized mean differences （SMD） and 95% confidence intervals （95% CI） of the pharmacokinetic parameters were calculated for comparison between subjects with TT genotype and mutant genotypes. Subgroup analyses were carried out for different ethnic populations and statin types, and sensitivity analysis was used to test the heterogeneity of the studies. Results Twenty-five studies were eligible for analysis, including 23 published in English and 2 in Chinese involving a total of 903 subjects. Meta-analysis of the studies showed that the SWD of the AUC0.inf of the subjects with TT - TC, TF - CC, and TF - （ TC ＋ CC） genotypes was 0.51 （95%CI： 0.29 -0.72） , 1.80 （95%CI： 1.31-2.29） and 0.78 （95%CI： 0.57 0. 99 ）, respectively, suggesting a higher SWD of AUC0.1.f in mutant genotypes than in the wild-type genotype. The same result was obtained in subgroup analysis of Caucasian and Asian populations. The SWD of C max in subjects with TF - TC, TF - CC, and TF - （TC ＋ CC） genotypes was 0.48 （95% CI： 0. 18 - 0.77）, 1.24 （95% CI： 0. 77 - 1.70） and 0.65 （95% CI： 0. 43 - 0. 87）, respectively, also higher in the mutant genotypes; subgroup analysis of Caucasian and Asian populations also yielded the same result. The SWD of CL/F in the subjects with the 3 genotypes was - 1.01 （95% CI： - 1.91 - -0.11 ）, - 1.51 （95% CI： -2.08 -0.94） and -1.07 （95%CI： -1.55 - -0