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microRNAs, an active and versatile group in cancers

ISSN号：1674-2818
期刊名称：International Journal of Oral Science
时间：2011.10.10
页码：165-175
分类：Q52[生物学—生物化学] X503.1[环境科学与工程—环境工程]
作者机构：[1]Department of Biological Sciences, University of Delaware, Nowak DE 19716, USA, [2]State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China, [3]Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China, [4]Cancer Biology Division, School of Medicine, Washington University, St. Louis MO 63108, USA
相关基金：We thank Xiao-wei Wang at Washington University in St. Louis for the proofreading. This work was supported by National Natural Science Foundation of China grants （No. 30872889, 81072215, 81001210, 81172580）, by Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry （No. 20098-8-2） and by State Key Laboratory of Oral Diseases Open Funding （SKLODOF2010-05） and the Fundamental Research Funds of the Central Universities of China （2011）.
相关项目：表观遗传与microRNA共同诠释SCF/c-kit/Slug信号通路调控涎腺腺样囊性癌侵袭转移的分子机制

关键词：小分子RNA, 癌症, miRNAs, 肿瘤抑制基因, 人类蛋白质, 非编码RNA, 生物学过程, 生物标志物, microRNAs, cancer, epithelial-mesenchymal transition, inflammation, cancer stem cells, drug resistance

中文摘要：

microRNAs (miRNAs) are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development. miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflam- mation, anti-cancer drug resistance, and regulation of cancer stem cells. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.

英文摘要：

microRNAs （miRNAs） are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development, miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflam- mation, anti-cancer drug resistance, and regulation of cancer stem ceils. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.

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