中文摘要：

目的：观察四君子汤对原发性肝癌术后患者T淋巴细胞和NK细胞的影响及意义。方法：将符合纳入标准的128例肝癌术后患者随机分为治疗组与对照组。治疗组患者口服四君子汤,对照组患者不另服用药物,观察比较两组患者术后肿瘤复发率及生存率。流式细胞仪测定两组患者第24个月外周血CD4^＋、CD8^＋和CD16^＋CD56^＋细胞水平,并进行数据分析。结果：治疗组患者第1、3年肿瘤复发率均低于对照组,差异均有显著性意义（P〈0.005）;治疗组患者第1、3年生存率均高于对照组,差异均有显著性意义（P〈0.001）;治疗组患者CD4~＋T细胞和NK细胞均高于对照组,差异均有显著性意义（P〈0.05）;治疗组患者CD8^＋T细胞与对照组比较,差异无显著性意义（P〉0.05）。结论：四君子汤提高肝癌术后患者生存率及降低肿瘤复发率的机制可能是调节T淋巴细胞和NK细胞的免疫功能所致。

英文摘要：

Objective：To observe the efficacy on the T lymphocyte and NK cell after hepatocellular carcinoma operation treated with sijunzi decoction.Methods：One hundred and twenty eight cases after hepatocellular carcinoma operation and complying with the inclusive criteria were randomized into treatment group and control group.Therapeutic group was treated with sijunzi decoction：and the tumor recurrence and survival situation of two groups were analyzed：CD4^＋,CD8^＋ and CD16^＋ CD56^＋ were detected with flow cytometry instrument at 24 months after operation.Results：The tumor recurrence rates of the treatment group at the first and the third year were lower than the control group（P〈 0.005）：the survival rate of the treatment group at the first and the third year were higher than the control group（P 〈0.001）：the rates of the CD4^＋ T cell and NK cell were higher than the control group（P〈0. 05）：the rates of the CD8^＋ T cell were lower than the control group（P〈0. 05）.Conclusion：The mechanism of Sijunzi decoction improving the survival rate and decreasing tumor recurrence rate of hepatocellular carcinoma patients with radical operation might be regulate T lymphocyte and NK cell immune function.