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基于降脂中药药性统计分析探讨高脂血症中医证素特点
  • ISSN号:1000-1719
  • 期刊名称:《辽宁中医杂志》
  • 时间:0
  • 分类:R589.2[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:[1]湖南中医药大学,湖南长沙410208, [2]湖南中医药大学第一附属医院,湖南长沙410007
  • 相关基金:国家自然科学基金项目(81373550)
中文摘要:

目的:通过对降脂中药药性统计分析探讨高脂血症中医证素特点。方法:利用CNKI等检索库针对近10年文献所报道的降血脂中药检索,对降脂中药的药性(四气、五味、归经、功效)进行聚类及主成分分析来探讨高脂血症的中医证素特点。结果:降血脂的单味中药数共140味;中药四气寒凉与温热比较,差异有统计学意义(P〈0.05),聚类及主成分分析结果示:五味共3个公因子,甘、苦、辛,分别所占成分比例为:37.6%、31.4%、18.09%,累积贡献率为87.14%,有统计学意义;归经共5个公因子,肝、肾、肺、脾、胃,分别所占成分比例为22.09%、12.45%、11.05%、10.72%,累积贡献率为70.03%,有统计学意义;功效共7个公因子,清热、补阴、理气、活血、补阳、祛痰、补气为主,分别所占成分比例为16.91%、13.24%、11.60%、11.10%、10.88%、10.24%,累积贡献率为73.99%,有统计学意义。结论:降脂中药四气以寒凉为主,五味以甘、苦、辛为主,归经主要在肝,其次为肺、肾、脾、胃,功效以清热、补阴、理气、活血、补阳、祛痰、补气为主——推测高脂血症中医病位证素主要在肝、肾、肺、脾、胃,尤与肝最为密切;中医病性证素以血热、气滞、血瘀、痰、阴虚、阳虚、气虚为主。

英文摘要:

Objective:Through lipid - lowering drugs medicinal statistical analysis to investigate the characteristics of TCM syndrome in hyperlipemia. Methods : Using century periodical CNKI retrieval database for cholesterol - lowering drugs reported in literatures from 2003 to 2013, by cluster and principal component analysis to explore the characteristics of TCM syndrome factor of hyperlipidemia on the medicinal properties of lipid - lowering medicine ( four properties, five flavors, channel tropism, efficacy). Results : The number of single lipid - lowering Chinese medicine was 140, compared between cold property with warm property, the difference was statistically significant ( P 〈 0.05). The results showed that three common factors in five flavors, sweet, bitter, pun- gent, respectively accounted for 37.6% ,31.4% , 18.09%. The cumulative contribution rate was 87.14% , with statistical signifi- cance ;five common factors in channel tropism, liver, kidney, lung, spleen, stomach, respectively accounted for the proportion of 22.09%, 12.45% ,11.05%, 10.72%. The cumulative contribution rate was 70.03% ,with statistical significance;seven common factors in efficacy, clearing heat, regulating vital energy, activating blood, eliminating phlegm, tonifying yin, tonifying yang, tonify- ing Qi,respeetively accounted for the proportion of 16.91%, 13.24%, 11.60%, 11. 10%, 10.88%, 10.24%. The cumulative contribution rate was 73.99% and there was statistical significance. Conclusion:Hyperlipidemia disease of TCM syndrome factor is mainly in the liver, kidney, lung, spleen, stomach, especially close with liver. Disease of TCM syndrome has a reputation for blood heat, blood stasis, phlegm and Qi stagnation, Qi deficiency, Yin deficiency, Yang deficiency.

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期刊信息
  • 《辽宁中医杂志》
  • 北大核心期刊(2014版)
  • 主管单位:辽宁省卫生和计划生育委员会
  • 主办单位:辽辽宁中医药大学
  • 主编:张立德
  • 地址:沈阳市皇姑区崇山东路79号
  • 邮编:110032
  • 邮箱:lnzy@vip.163.com
  • 电话:024-31207233
  • 国际标准刊号:ISSN:1000-1719
  • 国内统一刊号:ISSN:21-1128/R
  • 邮发代号:8-87
  • 获奖情况:
  • 中国自然科学核心期刊,中国生物医学核心期刊,中国中医药优秀期刊,中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2014版)
  • 被引量:51754