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Digital design of scaffold for mandibular defect repair based on tissue engineering
  • ISSN号:1673-1581
  • 期刊名称:JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
  • 时间:0
  • 页码:769-779
  • 分类:R782.22[医药卫生—口腔医学;医药卫生—临床医学]
  • 作者机构:[1]Key Laboratory of E & M(Zhejiang University of Technology),Ministry of Education & Zhejiang Province,Hangzhou 310032,China, [2]Affiliated Stomatology Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China
  • 相关基金:Project supported by the National Natural Science Foundation of China (No. 50905164); the Zhejiang Provincial Natural Science Foundation of China (No. Y2090835) Acknowledgements The authors are grateful to Dr. Wei-dong ZHU from the University of California at Davis, USA for his help in improving the English writing.
  • 相关项目:非均匀梯度结构骨组织工程支架优化设计与制造技术研究
中文摘要:

mandible 的缺点在最近的年里更经常发生,并且经由骨头移植的临床的修理操作是困难的进一步由于一些内在的缺陷被改善。织物工程,是生物医学的工程的一个热研究领域,为 mandible 的缺点修理提供一个新方向。作为基础和织物工程的关键部分,脚手架是广泛地并且深深地关于 biomaterial,结构,设计,和制造方法的基本理论,以及原则学习了。然而,很少研究都不为诊所修理操作目标为织物新生。因为 mandible 的骨头在存在研究有特殊结构,而非一致、常规的结构,方法论在这篇论文为 mandible 的缺点修理基于织物工程被建议。关键步考虑支架数字设计,例如外部形状设计和内部微观结构,设计直接详细基于三角形的网孔被讨论。由从快速的原型制作的测试部分分析理论模型和测量数据,建议方法论的可行性和有效性适当地被验证。关于要做在未来支持它的临床的申请的机械、生物的改进需要的更多的工作。

英文摘要:

Mandibular defect occurs more frequently in recent years,and clinical repair operations via bone transplantation are difficult to be further improved due to some intrinsic flaws.Tissue engineering,which is a hot research field of biomedical engineering,provides a new direction for mandibular defect repair.As the basis and key part of tissue engineering,scaffolds have been widely and deeply studied in regards to the basic theory,as well as the principle of biomaterial,structure,design,and fabrication method.However,little research is targeted at tissue regeneration for clinic repair operations.Since mandibular bone has a special structure,rather than uniform and regular structure in existing studies,a methodology based on tissue engineering is proposed for mandibular defect repair in this paper.Key steps regarding scaffold digital design,such as external shape design and internal microstructure design directly based on triangular meshes are discussed in detail.By analyzing the theoretical model and the measured data from the test parts fabricated by rapid prototyping,the feasibility and effectiveness of the proposed methodology are properly verified.More works about mechanical and biological improvements need to be done to promote its clinical application in future.

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期刊信息
  • 《浙江大学学报:B卷英文版》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:浙江大学
  • 主编:
  • 地址:杭州玉古路20号,浙江大学学报《英文版》编辑部
  • 邮编:310027
  • 邮箱:jzus@zju.edu.cn
  • 电话:0571-87952276 87952331
  • 国际标准刊号:ISSN:1673-1581
  • 国内统一刊号:ISSN:33-1356/Q
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  • 被引量:323