中文摘要：

Lycogarubin C和Lycogalic acid A是用于研究DNA拓扑异构酶I（Topo I）抑制剂的重要海洋天然产物.我们以叔丁基二甲硅基（TBS）保护的3-丁炔-1醇为起始原料,以二甲基1,2,4,5-四嗪-3,6-二羧酸酯与炔的杂/逆Diels-Alder反应为关键反应,经1,2-二嗪还原,Swern氧化,Fischer吲哚合成等八步反应实现了Lycogarubin C的全合成,再将Lycogarubin C以氢氧化钾处理得到Lycogalic acid A.

英文摘要：

Lycogarubin C and lycogalic acid A are key marine natural products which are used in studies on inhibitor of DNA Topoisomerase-I. With（but-3-ynyloxy）（tert-butyl）dimethylsilane as starting material, lycogarubin C was prepared in the process with 8 steps, via hetero-/retro-Diels-Alder reaction, reduction of 1,2-diazine, Swern oxidation, and Fischer indole synthesis as the key reactions, and lycogalic acid A was also obtained in the reaction of lycogarubin C with potassium hydroxide.