中文摘要：

采用膜片钳全细胞记录的方法研究了Sprague-Dawley（SD）大鼠初级视皮层Ⅱ/Ⅲ层内部侧向突触联系可塑性的动态发育变化及抑制性的GABA能神经联系在其中的作用,并通过记录抑制性突触后微电流（miniature inhibitory postsynaptic currents,mIPSCs）,探讨了抑制性GABA能突触及GABA受体在此过程中的变化.结果发现：SD大鼠在睁眼前后突触可塑性发生了很大的变化,睁眼前Ⅱ/Ⅲ层内部侧向刺激可以诱发出长时程增强（long-term potentiation,LTP）,而睁眼后LTP现象消失,该种突触可塑性的变化与抑制性GABA能突触数量的增多和突触后GABA受体数量的变化有关.

英文摘要：

In the present study,patch-clamp whole cell recording was used to investigate the developmental changes of the internal horizontal synaptic plasticity and the role of inhibitory GABAergic connections in these changes in layer Ⅱ/Ⅲ of Sprague-Dawley rats＇ primary visual cortices.And mIPSCs were examined to study the alteration of GABAergic synapse and GABA receptors in this process.We found that LTP could be induced from neurons in layer Ⅱ/Ⅲ by horizontal tetanic stimulation before eyes opening,but disappeared after eyes opening.This result indicated that synaptic plasticity underwent very significant changes during eyes opening.Our data also demonstrated that the increase of GABAergic synapse and GABA receptor played a critical role in the changes of synaptic strength in layer Ⅱ/Ⅲ.