中文摘要：

在哺乳动物的部分 hepatectomy (PHx ) 是一个很普通的试验性的模型调查肝新生的过程。外科本身能生产一系列压力，例如身体温度和 ischaemia-reperfusion 损害的暂时的加薪。热吃惊蛋白质(HSP ) 是涉及维持房间动态平衡并且调整免疫系统的压力可诱导的蛋白质的一个家庭。在我们的学习，我们打算在肝新生调查 HSP 的表示和角色。用 RT-PCR 并且西方的弄污，我们在分别地，在 mRNA 水平和蛋白质水平改革 HSP27， HSP60， HSP70 和 HSP90 的肝，鼠标与假冒的操作当作了控制决定了表达式。我们也把 quercertin 用作 HSP 的 inhibitior 在肝新生上探索他们的效果。我们发现 HSP 的那肝的表情在肝新生的早阶段增加了并且衰退了到组成地低级以后。而且，橡黄素预告的处理经由 HSP 的抑制在老鼠推迟了肝新生的进步。结果显示 HSP 在肝新生起了一个重要作用。

英文摘要：

Partial hepatectomy （PHx） in mammals is a very common experimental model to investigate the process of liver regeneration. The surgery itself could give birth to a series of stresses, such as the temporary raise of body temperature and the ischaemia-reperfusion injury. Heat shock proteins （HSPs） were a family of stress-inducible proteins involved in maintaining cell homeostasis and regulating the immune system. In our study, we intended to investigate the expression and role of HSPs in liver regeneration. Using RT-PCR and Western blotting, we determined the expression in regenerating liver of HSP27, HSP60, HSP70 and HSP90 in mRNA level and protein level, respectively, with mice treated with sham operation as controls. We also used quercertin as an inhibitior of HSPs to explore their effects on liver regeneration. We found that hepatic expression of HSPs increased at the early phase of liver regeneration and declined to the constitutively low level later. Moreover, quercetin pretreatment delayed the progress of liver regeneration in mice via inhibition of HSPs. The results indicated that HSPs played an important role in liver regeneration. Cellular ＆ Molecular Immunology. 2007;4（1）：53-57.