欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
天然蛋白质由20种天然氨基酸组成，这些蛋白质的构筑基元包含功能基团：羧基、氨基、巯基、硫醚、羟基、碱性胺、烷基和芳基。然而，这些有限的功能基团却不足以完成生物体内所有的生物学功能。为了更好地让生命的体现者——蛋白质完成更加精确和多样的生物学功能，自然界会对蛋白质进行翻译后的修饰，包括：磷酸化，甲基化，乙酰化或者羟基化，甚至在某些情况下，进化出一种新型的翻译机制以便插入硒代半胱氨酸或者吡咯霉素。受此启发，生物化学家发展出各种生物或化学方法来改变或插入新的蛋白质构筑基元，使天然蛋白质完成其相应的生物学功能或者使其具有某些特殊的性质，甚至是创造一种新酶。该文将简单介绍这些蛋白质修饰策略以及该领域的最新进展。
英文摘要：
Although 20 natural amino acids served as the building blocks of proteins contain several functional groups including carboxylic acids, amides, thiols, thiol ethers, alcohols, basic amines, and alkyl and aryl groups, they are still unable to carry out all of the natural functions. In order to improve the precision and diversity of protein to perform the biological processes, organisms have provided a variety of posttranslational modifications including phosphorylation, methylation, acetylation, and hydroxylation, even evolved novel translational machinery to incorporate either selenocysteine or pyrrolysine. Inspired by biological system, many biological or chemical methods have been developed to alter or insert new building blocks into protein, which enable protein to perform relevant functions or have some special properties, even create a new kind of enzyme. Here, we give a brief overview of the strategies for protein modification and the latest progress in this field
同期刊论文项目
同项目期刊论文
A supramolecular bifunctional artificial enzyme with superoxide dismutase and glutathione peroxidase
Giant Nanotubes Loaded with Artificial Peroxidase Centers: Self-Assembly of Supramolecular Amphiphil
2-Tellurium-bridged b-cyclodextrin, a thioredoxin reductase inhibitor, sensitizes human breast cance
Photoregulating Catalytic Activity of Cyclodextrin-Based Artificial Glutathione Peroxidase by Charge
A modulatory bifunctional artificial enzyme with both SOD and GPx activities based on a smart star-s
Design of Biomimetic Catalysts by Molecular Imprinting in Synthetic Polymers: The Role of Transition
Engineering human seleno-glutaredoxin containing consecutive rare codons as an artificial glutathion
Highly Ordered Protein Nanorings Designed by Accurate Control of Glutathione S?Transferase Self-Asse
Stucture of the complex between Mucor pusillus pepsin and the key domain of kappa-casein for site-di
Triple mutated antibody scFv2F3 with high GPx activity: insights from MD, docking, MDFE, and MM-PBSA
Construction of GPx Active Centers on Natural Protein Nanodisk/Nanotube: A New Way to Develop Artifi
A Dual Enzyme Microgel with High Antioxidant Ability Based on Engineered Seleno-Ferritin and Artific
Highly Ordered Protein Nanorings Designed by Accurate Control of Glutathione S-transferase Self-Asse
Construction of Protein Nanowires through Cucurbit[8]uril-based Highly Specific HostGuest Interactio
Self-assembled nanostructures from C(60)-containing supramolecular complex: its stimuli-responsive r
Construction of a smart glutathione peroxidase mimic with temperature responsive activity based on b
Hierarchical Self-Assembly of Surfactant-Encapsulated and Organically Grafted Polyoxometalate Comple
Preparation, Structure, and Imaging of Luminescent SiO2 Nanoparticles by Covalently Grafting Surfact
Drying and Nondrying Layer-by-Layer Assembly for the Fabrication of Sodium Silicate/TiO(2) Nanoparti
Embedding graphene nanoparticles into poly(N,N ';-dimethylacrylamine) to prepare transparent nanocom
A supramolecular gel based on an adenine symmetrically grafted Anderson-type polyoxometalate complex
Luminescent Dendrimers Composed of Quinacridone Core and Carbazole Dendrons: Structure, Electrochemi
Synthesis and redox-responsive self-assembly of ferrocene grafted Anderson-type polyoxometalate hybr
A green emissive amorphous fac-Alq(3) solid generated by grinding crystalline blue fac-Alq(3) powder
Self-assembly and supramolecular liquid crystals based on organic cation encapsulated polyoxometalat
Synthesis and characterizations of novel spindle-like terphenyl-type chromophores for non-linear opt
Nucleation of Aqueous Semiconductor Nanocrystals: A Neglected Factor for Determining the Photolumine
Bioinspired Water-Vapor-Responsive Organic/Inorganic Hybrid One-Dimensional Photonic Crystals with T
Coomassie Brilliant Dyes as Surface-Enhanced Raman Scattering Probes for Protein-Ligand Recognitions
Exponential growth of layer-by-layer assembled coatings with well-dispersed ultrafine nanofillers: a
Stable water-dispersed organic nanoparticles: preparation, optical properties, and cell imaging appl
Sensing of polycyclic aromatic hydrocarbons with cyclodextrin inclusion complexes on silver nanopart
A pluronic F127 coating strategy to produce stable up-conversion NaYF4:Yb,Er(Tm) nanoparticles in cu
Achieving high open-circuit voltage in the PPV-CdHgTe bilayer photovoltaic devices on the basis of t
Correlation between Annealing-Induced Growth of Nanocrystals and the Performance of Polymer: Nanocry
Theoretical study on the charge transport property of Pt((CNBu)-Bu-t)(2)(CN)(2) nanowires induced by
A Twisting Donor-Acceptor Molecule with an Intercrossed Excited State for Highly Efficient, Deep-Blu
Instantaneous and reversible gelation of organically grafted polyoxometalate complexes with dicarbox
Construction of nanoparticle superstructures on the basis of host-guest interaction to achieve perfo
Avoiding coffee ring structure based on hydrophobic silicon pillar arrays during single-drop evapora
Photo-Responsive Self-Assembly of an Azobenzene-Ended Surfactant-Encapsulated Polyoxometalate Comple
Surface Chemistry Routes to Modulate the Photoluminescence of Graphene Quantum Dots: From Fluorescen
Patterning Organic/Inorganic Hybrid Bragg Stacks by Integrating One-Dimensional Photonic Crystals an
Interfacial Charge-Transfer Effects in Semiconductor-Molecule-Metal Structures: Influence of Contact
Elevated Ag nanohole arrays for high performance plasmonic sensors based on extraordinary optical tr
Self-assembled gold nanocrystal micelles act as an excellent artificial nanozyme with ribonuclease a
An insight into the protection of rat liver against ischemia/reperfusion injury by 2-selenium-bridge
Construction of Smart Glutathione Peroxidase Mimic Based on Hydrophilic Block Copolymer with Tempera
期刊信息
位置：