中文摘要：

越来越多的证据表明,炎性微环境在肿瘤的发生、发展中发挥着重要的促进作用,炎性因子介导的信号通路参与了肿瘤细胞的恶性演进。细胞上皮-间质转型（epithelial-mesenchymal transition,EMT）是肿瘤恶性演进过程中的关键机制,炎性细胞因子（白细胞介素、TNF-α、TGF-β等）、EMT的关键转录因子[锌指E盒结合同源盒蛋白（zinc finger E-box-binding homeobox,ZEB）、Snail和Twist等]及某些miRNA（let-7、miR-200等）共同构成复杂的调控网络,调控肿瘤细胞的表型转化、药物抗性的产生、肿瘤干细胞（cancer stem cell,CSC）的增殖及自我更新。本文将重点讨论炎症及相关信号通路在肿瘤发生、发展以及CSC形成过程中的调控机制。

英文摘要：

Increasing evidence indicated that tumor inflammatory microenviroment plays an important role in cancer initiation and development.The signaling pathways mediated by inflammatory cytokines participate in malignant transformation of tumor cells.Epithelial-mesenchymal transition（EMT） is a critical mechanism underlying transformation of tumor cells.A network composed by inflammatory cytokines（interleukin,TNF-α and TGF-β）,key transcription factors of EMT,including zinc finger E-box-binding homeobox（ZEB）,Snail and Twist,and some miRNAs（let-7 and miR-200） regulates malignant transformation of tumor,generation of drug resistance and the proliferation and the self-renewal of cancer stem cell（CSC）.This article reviews the recent studies on the molecular mechanisms,by which inflammation and related signaling pathways regulate tumor initiation,development and CSC formation.