中文摘要：

目的 检测广西地区骨与关节结核患者外周血中白细胞介素-23（IL-23）的表达水平并探讨其临床意义.方法 收集2015年7月~2016年7月收治的45例骨与关节结核患者作为观察组, 选择同期在体检中心进行健康体检的54名健康者作为对照组.采用免疫酶联吸附法（ELISA）检测两组外周血血清IL-23的表达水平,同时采用常规方法对C反应蛋白（CRP）和红细胞沉降率（ESR）进行检测,比较两组间IL-23、CRP及ESR表达水平的差异,分析观察组IL-23水平与CRP、ESR水平之间的相关性.结果 两组受试者外周血IL-23、CRP及ESR表达含量差异有统计学意义（P〈0.001）.观察组IL-23、CRP及ESR水平均显著高于对照组;观察组外周血IL-23与CRP、ESR水平均无线性相关（P〉0.05）.结论 广西地区骨与关节结核患者外周血中IL-23的表达水平明显升高,提示其可能在骨与关节结核发病中起重要作用.

英文摘要：

Objective To detect the expression of interleukin-23（IL-23） level in peripheral blood of patients with bone and joint tuberculosis in Guangxi and to explore its clinical significance.Methods Forty-five patients with bone and joint tuberculosis admitted to our hospital from July,2015 to July,2016 were selected as observation group.And fifty-four healthy subjects were selected as control group.The levels of serum IL-23 in peripheral blood were measured by enzyme-linked immunosorbent assay（ELISA） in both groups and the levels of plasma C reactive protein（CRP） and erythrocyte sedimentation rate（ESR） were tested by routine method.The difference of levels of IL-23,CRP and ESR was compared between the two groups and correlation between IL-23 levels and CRP,ESR levels in the observation group was analyzed.Results Difference of expression levels of IL-23,CRP and ESR in peripheral blood of both groups was statistically significant（P〈0.001）.The levels of IL-23,CRP and ESR in the observation group were significantly higher than those in the control group,and there was no linear correlation between IL-23 and CRP and ESR in the peripheral blood of the observation group（P〉0.05）.Conclusion The expression of IL-23 in peripheral blood of patients with bone and joint tuberculosis in Guangxi significantly increases,which suggests that IL-23 may play an important role in the pathogenesis of bone and joint tuberculosis.