中文摘要：

失重或模拟失重会导致血管的结构和功能发生区域特异性改变,并影响血管内皮细胞形态和功能,引起相关基因和分子的表达变化。研究发现引起这些改变的机制包括离子通道变化、eNOS和iNOS的变化、细胞骨架改变等。目前人们初步探索了间断重力刺激等措施用于干预失重后血管及血管内皮细胞形态和功能的改变。

英文摘要：

Weightlessness or simulated weightlessness can lead to some changes of vascular structure and functions regionspecifically and has an influence on the morphology and ultrastructure of vascular endothelial cells, causing expression changes of some related genes and molecules. Current studies show that multiple mechanisms are involved in these changes such as ion channels,the expression changes of eNOS and iNOS as well as cytoskeletal rearrangement. Some measures such as intermittent artificial gravity have been applied to counter the morphological and functional changes of vessels and vascular endothelial cells which result in cardiovascular deconditioning.