目的:观察早期衰老大鼠视网膜色素上皮-光感受器细胞复合体超微结构的变化。方法:取3月龄及12月龄大鼠视网膜,制成半薄切片,透射电镜下观察视网膜色素上皮-光感受器细胞复合体超微结构的变化。结果:12月龄大鼠视网膜中出现视网膜色素上皮细胞(retinal pigment epithelium,RPE)凋亡和RPE-光感受器细胞复合体的退行性改变。结论:视网膜色素上皮-光感受器细胞复合体的退行性改变是视网膜衰老的早期表现。
AIM: To observe the ultrastructural changes of retinal pigment epithelium (RPE) - photoreceptor complex in early aging rats. METHODS: Retinas of 3-month old and 12-month old rats were prepared into semi- thin sections and then observed under transmission electron microscope to evaluate the changes of RPE-photoreceptor complex. RESULTS: Apoptosis of RPE cells and degenerative changes of RPE-photoreceptor complex were found in retinas of 12-month old rats. CONCLUSION: RPE-photoreceptor complex degeneration is an early manifestation of the retinal aging.