中文摘要：

目的探讨APOBEC3G在慢性乙型肝炎和肝癌组织中的表达，及与慢性乙型肝炎和肝癌的关系。方法应用免疫组织化学方法检测45例肝组织（正常肝组织8例，慢性乙型肝炎肝组织6例，肝癌组织21例，癌旁组织10例）中APOBEC3G的表达，采用半定量积分法判断表达的强度。结果APOBEC3G在正常肝组织中无表达或仅见少量表达（表达阳性率12．5％），而在慢性乙型肝炎肝组织中、肝癌组织中和癌旁组织中均有较强表达（表达阳性率分别为83．3％、66．7％、50．0％），其差异有统计学意义（P〈0．01）。APOBEC3G在肝组织中的表达强度与同组中HBsAg、HBcAg的表达强度无明显相关（P〉0．05）。结论慢性HBV感染能促使肝细胞内APOBEC3G表达增高，但APOBEC3G高水平的表达与HBsAg、HBcAg的表达强度无明显相关。

英文摘要：

Objective To examine the expression of APOBEC3G in liver tissues, including normal control,chronic hepatitis B ,hepatocellular carcinoma and para-cancerous tissue,and to investigate the relationship between the expression of APOBEC3G and hepatitis B virus infection. Methods Immunohistochemistry was used to detect the expression levels of APOBEC3G in liver tissues of 45 cases （8 healthy controls ,6 cases of chronic hepatitis B,21 cases of hepatocellular carcinoma and 10 cases of para-cancerous tissues）. The expression intensity of APOBEC3G was determined by using semiquantitative integration methods. Results APOBEC3G expression levels in liver tissues of chronic hepatitis B ,hepatocellular carcinoma and para-cancer （positive rate was 83.3% ,66.7% and 50.0% respectively） were higher than that in healthy controls （positive rate was 12.5% ） （P 〈 0.01 ）. There was no relationship between the expression levels of APOBEC3G and HBsAg or HBcAg （ P 〉 0.05 ）. Conclusion HBV infection could increase the expression levels of APOBEC3G, but the overexpression of APOBEC3G is not associated with the expression of HBsAg and HBcAg.