中文摘要：

目的探讨恶性肿瘤并静脉血栓栓塞症患者的相关危险因素。方法收集2015年11月-2016年9月在新疆维吾尔自治区人民医院住院患者病例资料及血样标本79例,包括17例确诊恶性肿瘤并静脉血栓栓塞症患者（合并组）,同期31例确诊单纯恶性肿瘤患者（单纯肿瘤组）及31例确诊单纯静脉血栓栓塞症患者（单纯栓塞组）。血样标本通过双抗体一步夹心法酶联免疫吸附试验（ELISA）检测血清因子含量。结果恶性肿瘤合并静脉血栓栓塞症多发生于高龄、肥胖、肿瘤中晚期、近期术后制动的患者。合并组患者以肺部恶性肿瘤合并静脉血栓栓塞症多见,其病理类型以腺癌为主,其次为消化系统、血液系统、泌尿生殖系统。合并组与单纯肿瘤组比较,ADAMTS-13、TT值减低,vW F、D-D、FIB值升高,有显著统计学差异（P〈0.001）。合并组与单纯栓塞组上述指标比较,差异无统计学意义（P〉0.05）。接受正规治疗的患者,合并组好转8例,无效5例,死亡4例,单纯栓塞组好转25例,无效4例,死亡2例。合并组无效或死亡的比例明显高于单纯栓塞组（P〈0.05）。结论高龄、肥胖、肿瘤中晚期、近期术后制动的恶性肿瘤患者更易发生静脉血栓栓塞症。ADAMTS-13、vW F、D-D、FIB可能均具备独立预测静脉血栓栓塞风险的意义。恶性肿瘤合并静脉栓塞症预后较差,我们应对静脉栓塞高危人群进行早期干预与治疗。

英文摘要：

Objective To explore the related risk factors for patients with malignant tumor and venous thromboembolism. Methods The clinicaldata and blood samples of 79 patients in People＇s Hospital of Xinjiang UygurA utonomousR egion were collected from 2015 November to 2016 September,including 17 cases of patients diagnosed with malignant tumor and venous thromboembolism（combined group）,31 cases of patients diagnosed with malignant tumor（the tumor group）,and 31 cases of patients diagnosed with venous thromboembolism（the embolism group）. Serum factors were detected in all the blood samples by ELISA. Results Older age,obesity,cancer progression,recent operation brake may be the risk factors of tumor combined with venous thromboembolism. Pulmonary malignant tumor with venous thromboembolism was more common in the combined group,of which the major pathological type was adenocarcinoma,followed by the digestive system,blood system and urogenital system. Compared with tumor group,ADAMTS-13 and TT value were decreased,vW F,D-D and FIB value were increased significantly in the combined group（P〈0.001）. There were no statistically significantly differences between the combined group and the embolism group（P〈0.05）. 8 patients were improved,5 cases patients were ineffective,and 4 patients died after formal treatment in the combined group. 25 patients were improved,4 cases patients were ineffective,and 2 patients died after formal treatment in the embolism group. Invalid or death ratio of combined group was obviously higher than that of the embolism group（P〈0.05）. Conclusion Older age,obesity,cancer progression,recent operation brake may be the risk factors of tumor combined with venous thromboembolism. Pulmonary cancer with venous thromboembolism was more common.Difficulty breathing,chest tightness,chest pain and shortness of breath can imply the occurrence of pulmonary embolism. ADAMTS-13,vW F,D-D,FIB may be used to predict VTE independently. Malignant tumor with venous thrombosis disease is related wit