Rab11是Rab小分子GTP酶家族的成员。在细胞内膜泡再循环途径中,Rab11作为重要调节因子,介导膜泡从内体向质膜的运输。近年来随着对Rab11研究的深入,人们发现该蛋白质在多种细胞生命活动中发挥着关键作用。现对Rab11的结构、效应蛋白及功能等方面进行了综述。
Rab11 is one of the members of Rab protein family, which belongs to small GTPases. As an important regulator on vesicular recycling pathways, Rab11 mainly controls the transport of vesicles from endosomes to plasma membrane. Recent researches have been supported that Rab11 plays pivotal role in manifold processes of cell. In this review, the advances on structure, interaction proteins and functions of Rab11 are introduced.