中文摘要：

在血类脂化合物上观察红酵母米饭(RYR ) 的效果的目的铺平，大动脉的动脉粥样硬化(作为) ，并且在 apolipoprotein E 基因大美人(ApoE-/-) 的匾稳定性老鼠。24 只 ApoE-/- 老鼠用一本高脂肪的食谱从 6 星期年龄开始被喂的方法。老鼠被使随机化进三个组(8 在各个组织的 n =) ：模型组(ApoE-/- 组) ， RYR 组(ApoE-/-+ RYR 组) ，和 simvastatin 组(ApoE-/-+ simvastatin 组) 。八个 6-week-old C57BL/6 鼠标作为控制组被分配并且用一本基本食谱喂了。在 36 个星期以后，血浆类脂化合物和 inflflammatory 因素被测量。由显微镜，扫描电子显微镜和传播电子显微镜的大动脉的动脉粥样硬化患者损害被观察。interleukin-6 (IL-6 ) 和肿瘤坏死因素的血浆层次 --(TNF-) 与连接酶的 immunosorbent 被测量试金。高敏感 C 反应蛋白质(Hs-CRP ) 的水平被散布 immunoturbidimetric 试金检测。矩阵 metalloproteinase-9 (MMP-9 ) 和在主动脉的原子因素 B (NF-B ) 的蛋白质表示被 immunohistochemistry 测试。结果与模型组，相比，有 RYR 的处理显著地减少了在 ApoE-/- 老鼠的全部的胆固醇， triglyceride，低密度的脂蛋白胆固醇，脂蛋白(a) ，和 apolipoprotein B100 的层次(P < 0.01 ) 。与模型组相比，有 RYR 的处理减少了 Hs-CRP， IL-6，和 TNF- 的层次(P < 0.01 ) 。RYR 也减少了 NF-B 的蛋白质层次和主动脉的 MMP-9。结论 RYR 有反动脉粥样硬化患者和稳定的不稳定的匾效果。机制可能与表明小径的 inflflammatory 有关。

英文摘要：

Objective： To observe the effects of red yeast rice（RYR） on blood lipid levels, aortic atherosclerosis（AS）, and plaque stability in apolipoprotein E gene knockout（Apo E-/-） mice. Methods： Twentyfour Apo E-/-mice were fed with a high-fat diet starting from 6 weeks of age. Mice were randomized into three groups（n = 8 in each group）： model group（Apo E-/-group）, RYR group（Apo E-/-＋ RYR group）, and simvastatin group（Apo E-/-＋ simvastatin group）. Eight 6-week-old C57BL/6 mice were assigned as the control group and fed with a basic diet. After 36 weeks, plasma lipids and inflammatory factors were measured. Aortic atherosclerotic lesions by microscope, scanning electron microscope and transmission electron microscope were observed. Plasma levels of interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） were measured with enzymelinked immunosorbent assay. The level of high sensitivity C-reaction protein（Hs-CRP） was detected by the scattering immunoturbidimetric assay. Protein expression of matrix metalloproteinase-9（MMP-9） and nuclear factor κB（NF-κB） in aorta were tested by immunohistochemistry. Results： Compared with the model group, treatment with RYR significantly decreased the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, lipoprotein（a）, and apolipoprotein B100 in Apo E-/-mice（P〈0.01）. Compared with the model group, treatment with RYR decreased the levels of Hs-CRP, IL-6, and TNF-α（P〈0.01）. RYR also reduced the protein levels of NF-κB and MMP-9 of the aorta. Conclusions： RYR has the anti-atherosclerotic and stabilizing unstable plaque effects. The mechanism might be related to the inflammatory signaling pathways.