中文摘要：

以N-甲基-4-哌啶酮和芳甲醛衍生物为原料，分别以10％的氢氧化钠乙醇溶液和干燥的氯化氢气体作催化剂，室温下羟醛缩合反应7～8h，TLC检测反应进程，合成了3种N-甲基-3，5-二芳亚甲基-4-哌啶酮衍生物，质量收率达到49％以上，并以。HNMR结合熔点对其结构进行了表征。结果表明，该合成路线反应条件温和，操作简便。

英文摘要：

Starting from N-methyl-4-piperidone and formaldehyde derivatives, the targeted compounds were synthesized with 10% alcoholic NaOH or dry hydrogen chloride as catalyst via aldol condensation reaction at room temperature for 7- 8 h. The reaction was monitored by TLC. Three 3,5-bis（arylidene）-4-piperidones were successfully synthesized with the yields above 49%. The structures were characterized by 1 H NMR and melting points measurement. This was a convenient and efficient method with high yields. The compounds synthesized are used for antitumour evaluation.