中文摘要：

随着细胞内信号通路的研究进展，肿瘤分子靶向治疗逐渐成为研究的热点。src蛋白与肿瘤的关系十分密切．在多种肿瘤细胞中高度活化和／或过量表达，与体内的多条信号通路相联系，可被多条信号转导途径所激活。并能够促进肿瘤的发生和发展。因此，达沙替尼、塞卡替尼、博舒替尼等Src蛋白的抑制剂在肿瘤中的作用逐渐引起人们的关注。

英文摘要：

With the progress of the study of intracellular signaling pathways, tumor molecular targeted therapy has gradually become a hot spot. Src protein which is highly activated in a variety of tumor cells and/or overexpression hasa close relationship with tumors. It has been linked to multiple signaling pathways. Src protein can be activated by multiple signal pathways and promote tumorigenesis and progression. Therefore, dasatinib, imatinib, bosutinib and other inhibitors of Src protein has gradually attracted people＇ s attention.