有代替的吲哚的 o-alkynylbenzaldehydes 或 o-alkynylbenzaldimines 的催化双人脚踏车反应由羰基或 imine 组的吲哚的分子间的增加开始了的 Pd (II ) 由 intramolecular 炔属羟的 nucleopalladation 列在后面,由 protonolysis 熄灭碳钯契约改革 Pd (II ) 种类被开发。没有一个氧化还原作用系统的必要性,反应能在温和条件下面被执行。
A Pd(II) catalyzed tandem reaction of o-alkynylbenzaldehydes or o-alkynylbenzaldimines with substituted indoles initiated by the intermolecular addition of indoles to the carbonyl or imine group followed by the nucleopalladation of an intramolecular alkyne and quenching the carbon-palladium bond by protonolysis to regenerate the Pd(II) species was developed. The reaction can be carried out under mild conditions without the necessity of a redox system.