中文摘要：

一直以来,人们普遍认为CD4＋T辅助细胞（Th）受到外来抗原刺激可分化为具有不同表型、细胞因子分泌特征及功能的T细胞亚群Th1、Th2、Th17及调节性T细胞（Treg）。然而,近年来随着研究的深入,一群与上述已知的T细胞亚群不同的CD4＋Th细胞被发现,这群T细胞的分化过程需要白细胞介素4（IL-4）及转化生长因子β（TGF-β）的协同刺激,并且主要分泌IL-9和IL-10,因此被命名为Th9。越来越多的证据表明,Th9与多种疾病密切相关。本文就近年来Th9的发现、诱导及培养特性,以及在移植免疫等相关疾病中的作用做一综述。

英文摘要：

For a long time,it is generally accepted that CD4＋ T helper cells（Th） can be differentiated into Th1,Th2,Th17 and regulatory T cells（Treg） subgroups with different phenotypes,cytokine secretion characteristics and functions under the stimulation of foreign antigens.In recent years,however,a new group of CD4＋ T cell subset that was different from above known CD4＋ Th cells was found,and it was shown that the differentiation process of this group of T cell needs the co-stimulation of interleukin-4 and transforming growth factor-β.Because of the secretion of IL-9 and IL-10 by this group of T cells,they were named as Th9.A growing evidence suggests that Th9 is closely related to many diseases.In this review,we focus on the discovery,induction,cultivation,and the role of Th9 in transplantation immunity-related diseases,in order to acquire its comprehension.