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中文摘要：
目的对雷尼酸锶在骨质疏松症中的临床应用、作用机制进行综述和评价。方法从人群试验、动物试验、细胞培养和不良反应等方面进行综述。结果雷尼酸锶具有抗骨吸收和增进骨形成双重作用，其作用可能通过CaSR和增加血清IGF-1、降低高半胱氨酸。结论雷尼酸锶作为一种新型抗骨质疏松药物，对骨质疏松症具有良好的疗效，代表了骨质疏松症治疗的一个重要发展方向，但应注意其不良反应。
英文摘要：
Objective To evaluate the roles of strontium ranelate for clinical application and mechanism in patients with osteoporosis. Methods This article reviewed the advancement of strontium ranelate, which summarized from crowd testing, animal testing, cell culture and adverse reactions. Results Strontium ranelate can promote bone formation and decrease bone resorption, its role may be through the CaSR and increase serum IGF-1, to reduce homocysteine expression. Conclusion Strontium ranelate is a new anti-osteoporosis drug for osteoporosis. It has a good curative effect, represents the treatment direction of osteoporosis, but we should pay attention to its adverse reactions.
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