中文摘要：

以盐酸克伦特罗为模板分子,采用沉淀聚合法合成了克伦特罗的分子印迹聚合物,并以其为离子载体,制得分子印迹聚合物膜克伦特罗离子选择性电极。在最优实验条件下,电极对克伦特罗阳离子的检出限可达7.0×10-8mol/L,线性范围为1.0×10-7～1.0×10-4mol/L,能斯特斜率为55.7 mV/decade。此电极具有优越的选择性、快速的响应时间以及良好的稳定性;已成功应用于实际猪尿样品中克伦特罗的测定,加标回收率为98%～107%,检测时间小于3 min。

英文摘要：

A polymeric membrane ion-selective electrode for the determination of clenbuterol is described.It is based on a molecularly imprinted polymer（MIP） as an ionophore for molecular recognition,which can be synthesized by precipitation polymerization using clenbuterol hydrochloride as a template molecule.Under the optimized conditions,the proposed membrane electrode exhibits Nernstian response to the protonated clenbuterol over the concentration range of 1.0×10-7-1.0×10-4 mol/L with a slope of 55.7 mV/decade,and the detection limit is 7.0×10-8 mol/L.The MIP-based sensor shows excellent selectivity,rapid response time and satisfactory long-term stability.The potentiometric sensor has been successfully applied to determine the clenbuterol in pig urine samples with recoveries between 98% and 107% and an analytical time of less than 3 min.